Publications

We present the synthesis, properties, and biological applications of Peroxyfluor-1 (PF1), a new type of optical probe for intracellular imaging of hydrogen peroxide in living biological samples. PF1 utilizes a boronate deprotection mechanism to provide unprecedented selectivity and optical dynamic range for detecting H2O2 in aqueous solution over similar reactive oxygen species including superoxide, nitric oxide, tert-butyl hydroperoxide, and hydroxyl radical. We further demonstrate the value of this reagent for biological applications by imaging changes in [H2O2] in living mammalian cells.

Supernova (SN) 2005ip was a Type IIn event notable for its sustained strong interaction with circumstellar material (CSM), coronal emission lines and infrared (IR) excess, interpreted as shock interaction with the very dense and clumpy wind of an extreme red supergiant. We present a series of late- time spectra of SN 2005ip and a first radio detection of this SN, plus late-time X-rays, all of which indicate that its CSM interaction is still strong a decade post- explosion. We also present and discuss new spectra of geriatric SNe with continued CSM interaction: SN 1988Z, SN 1993J and SN 1998S. From 3 to 10 yr post- explosion, SN 2005ip's Ha luminosity and other observed characteristics were nearly identical to those of the radio- luminous SN 1988Z, and much more luminous than SNe 1993J and 1998S. At 10 yr after explosion, SN 2005ip showed a drop in Ha luminosity, followed by a quick resurgence over several months. We interpret this Ha variability as ejecta crashing into a dense shell located less than or similar to 0.05 pc from the star, which may be the same shell that caused the IR echo at earlier epochs. The extreme Ha luminosities in SN 2005ip and SN 1988Z are still dominated by the forward shock at 10 yr post- explosion, whereas SN 1993J and SN 1998S are dominated by the reverse shock at a similar age. Continuous strong CSM interaction in SNe 2005ip and 1988Z is indicative of enhanced mass- loss for similar to 10(3) yr before core collapse, longer than Ne, O or Si burning phases. Instead, the episodic mass- loss must extend back through C burning and perhaps even part of He burning.

Abstract It is well known that massive stars ( M > 8 M ☉ ) evolve up to the collapse of the stellar core, resulting in most cases in a supernova (SN) explosion. Their heterogeneity is related mainly to different configurations of the progenitor star at the moment of the explosion and to their immediate environments. We present photometry and spectroscopy of SN 2010bt, which was classified as a Type IIn SN from a spectrum obtained soon after discovery and was observed extensively for about 2 months. After the seasonal interruption owing to its proximity to the Sun, the SN was below the detection threshold, indicative of a rapid luminosity decline. We can identify the likely progenitor with a very luminous star (log L / L ☉ ≈ 7) through comparison of Hubble Space Telescope images of the host galaxy prior to explosion with those of the SN obtained after maximum light. Such a luminosity is not expected for a quiescent star, but rather for a massive star in an active phase. This progenitor candidate was later confirmed via images taken in 2015 (∼5 yr post-discovery), in which no bright point source was detected at the SN position. Given these results and the SN behavior, we conclude that SN 2010bt was likely a Type IIn SN and that its progenitor was a massive star that experienced an outburst shortly before the final explosion, leading to a dense H-rich circumstellar environment around the SN progenitor.

Abstract The title reactions occur with a variety of aliphatic, aryl, and heteroaryl allylic benzoates to form the corresponding allylic substitution products in high yields with good to excellent enantioselectivity with a scope that encompasses a range of anionic carbon and heteroatom nucleophiles.

This paper describes how building designers make sense of the sky and modern visualization techniques for representing them.The dialectic approach addresses technological innovation with respect to existing social practices.This is done for two reasons-to illustrate where practices are and how they can be extended with innovative technologies.It is shown that building designers maintain various levels of expertise for managing daylight design.Visualization prototypes are introduced also with different degrees of precision.The paper concludes with implications for the development of design tools and use by building designers.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

We study 34 Type Ic supernovae that have broad spectral features (SNe Ic-BL). This is the only SN type found in association with long-duration gamma-ray bursts (GRBs). We obtained our photometric data with the Palomar Transient Factory (PTF) and its continuation, the intermediate PTF (iPTF). This is the first large, homogeneous sample of SNe Ic-BL from an untargeted survey. Furthermore, given the high observational cadence of iPTF, most of these SNe Ic-BL were discovered soon after explosion. We present K-corrected Bgriz light curves of these SNe, obtained through photometry on template-subtracted images. We analyzed the shape of the r-band light curves, finding a correlation between the decline parameter Δm15 and the rise parameter Δm−10. We studied the SN colors and, based on g − r, we estimated the host-galaxy extinction for each event. Peak r-band absolute magnitudes have an average of −18.6 ± 0.5 mag. We fit each r-band light curve with that of SN 1998bw (scaled and stretched) to derive the explosion epochs. We computed the bolometric light curves using bolometric corrections, r-band data, and g − r colors. Expansion velocities from Fe <ns0:sc>II</ns0:sc> were obtained by fitting spectral templates of SNe Ic. Bolometric light curves and velocities at peak were fitted using the semianalytic Arnett model to estimate ejecta mass Mej, explosion energy EK and 56Ni mass M(56Ni) for each SN. We find average values of Mej = 4 ± 3 M⊙, EK = (7 ± 6)×1051 erg, and M(56Ni)=0.31 ± 0.16 M⊙. The parameter distributions were compared to those presented in the literature and are overall in agreement with them. We also estimated the degree of 56Ni mixing using scaling relations derived from hydrodynamical models and we find that all the SNe are strongly mixed. The derived explosion parameters imply that at least 21% of the progenitors of SNe Ic-BL are compatible with massive (> 28 M⊙), possibly single stars, whereas at least 64% might come from less massive stars in close binary systems.