Catalytic hydroarylation of alkenes is a desirable process because it can occur under neutral conditions with regioselectivity complementary to that of acid-catalyzed reactions and stereoselectivity derived from the catalyst. We report an intermolecular asymmetric addition of the C-H bonds of indoles, thiophenes, pyrroles, and furans to bicycloalkenes in high yield with high enantiomeric excess. These heteroarene alkylations occur ortho to the heteroatom. This selectivity is observed even with unprotected indoles, which typically undergo alkylation at the C3 position. Initial mechanistic studies revealed that oxidative addition of a heteroarene C-H bond to a neutral Ir(I) species occurs within minutes at room temperature and occurs in the catalytic cycle prior to the turnover-limiting step. Products from syn addition of the C-H bond across the olefin were observed.
Imagine visiting your favorite place, taking a few pictures, and then turning those pictures into a photorealisic three-dimensional computer model. The work presented in this thesis combines techniques from computer vision and computer graphics to make this possible. The applications range from architectural planning and archaeological reconstructions to virtual environments and cinematic special effects. This thesis presents an
This article explores the physical and emotional health status of 71 African-American grandmothers raising their grandchildren as a result of the crack cocaine involvement of the children's parents. A comparison of self-assessed health ratings with qualitative responses revealed a tendency for respondents to downplay their own health problems and symptoms.
Advisor Perspectives welcomes guest contributions. The views presented here do not necessarily represent those of Advisor Perspectives. This is an update of the authors ' 6 April 2009 column comparing today's global crisis to the Great Depression. World industrial production, trade, and stock markets are diving faster now than during 1929-30. Fortunately, the policy response to date is much better. The update shows that trade and stock markets have shown some improvement without reversing the overall conclusion-- today's crisis is at least as bad as the Great Depression. Editor’s note: The 6 April 2009 Vox column by Barry Eichengreen and Kevin O’Rourke shattered all Vox readership records, with 30,000 views in less than 48 hours and over 100,000 within the week. The authors will update the charts as new data emerges; this updated column is the first, presenting monthly data up to April 2009. (The updates and
This paper introduces an analytic method to determine the sensitivity to random parameter variations of analog VLSI neural network architectures for linear image filtering. The authors compare the robustness of several different circuit architectures for low pass filtering. This method can also determine which components within a particular architecture should specified the most precisely.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Certain necessary conditions for energy-minimizing states of fluid systems consisting of bulk, surface, and line phases are discussed. These include generalizations of the Laplace and Young equations of equilibrium, together with a demonstration that the line tension associated with a three-phase contact curve must be nonnegative.
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One of the many benefits of multicast, when compared to traditional unicast, is that multicast reduces the overall network load. While the importance of multicast is beyond dispute, there have been surprisingly few attempts to quantify multicast's reduction in overall network load. The only substantial and quantitative effort we are aware of is that of Chuang and Sirbu [3]. They calculate the number of links L in a multicast delivery tree connecting a random source to m random and distinct network sites; extensive simulations over a range of networks suggest that L(m) &prop; m 0.8 . In this paper we examine the function L(m) in more detail and derive the asymptotic form for L(m) in k-ary trees. These results suggest one possible explanation for the universality of the Chuang-Sirbu scaling behavior.