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Fazit Eine intravasale Bindung von Stickstoffmonoxid durch eine modifizierte Hämoglobinlösung führt im septischen Schock zu keiner Reduktion der Mortalität, sondern bei besonders schwer erkrankten Patienten sogar zu einer erhöhten Mortalität.
Quantifying organ dysfunction in patients with sepsis can assist in assessing prognosis and determining treatment effectiveness. The simplicity, reliability, and reproducibility of current scores facilitate their widespread use.
ENHANCE provides supportive evidence for the favorable benefit/risk ratio observed in PROWESS and suggests that more effective use of drotrecogin alfa (activated) might be obtained by initiating therapy earlier.
During low-flow states associated with tamponade, both dobutamine and norepinephrine at the dose used increased cardiac index, DO2, and VO2, but dobutamine delayed the onset of tissue hypoxia by further increasing blood flow and oxygen availability. In the conditions of the present study, neither agent significantly influenced the oxygen extraction capabilities of the body.
info:eu-repo/semantics/published
