Publications

High lactate concentrations on admission were an independent predictor of poor neurological recovery post-CA, but the time course was not related to outcome. Prolonged resuscitation, use of vasopressors, high PaO₂ and altered renal function were predictors of high lactate concentrations.

Background Alterations in skin blood flow is a marker of inadequate tissue perfusion in critically ill patients after initial resuscitation. The effects of red blood cell transfusions (RBCT) on skin perfusion are not described in this setting. We evaluated the effects of red blood cell transfusions on skin tissue perfusion in critically ill patients without acute bleeding after initial resuscitation. Methods A prospective observational study included 175 non-bleeding adult patients after fluid resuscitation requiring red blood cell transfusions. Using laser Doppler, we measured finger skin blood flow (SBF) at skin basal temperature (SBF BT ), together with mean arterial pressure (MAP), heart rate (HR), hemoglobin (Hb), central venous pressure (CVP), lactate, and central or mixed venous oxygen saturation before and 1 h after RBCT. SBF responders were those with a 20% increase in SBF BT after RBCT. Results Overall, SBF BT did not significantly change after RBCT [from 79.8 (4.3–479.4) to 83.4 (4.9–561.6); p = 0.67]. A relative increase equal to or more than 20% in SBF BT after RBCT (SBF responders) was observed in 77/175 of RBCT (44%). SBF responders had significantly lower SBF BT [41.3 (4.3–279.3) vs. 136.3 (6.5–479.4) perfusion units; p < 0.01], mixed or central venous oxygen saturation (62.5 ± 9.2 vs. 67.3% ± 12.0%; p < 0.01) and CVP (8.3 ± 5.1 vs. 10.3 ± 5.6 mmHg; p = 0.03) at baseline than non-responders. SBF BT increased in responders [from 41.3 (4.3–279.3) to 93.1 (9.8–561.6) perfusion units; p < 0.01], and decreased in the non-responders [from 136.3 (6.5–479.4) to 80.0 (4.9–540.8) perfusion units; p < 0.01] after RBCT. Pre-transfusion SBF BT was independently associated with a 20% increase in SBF BT after RBCT. Baseline SBF BT had an area under receiver operator characteristic of 0.73 (95% CI, 0.68–0.83) to predict SBF BT increase; A SBF BT of 73.0 perfusion units (PU) had a sensitivity of 71.4% and a specificity of 70.4% to predict SBF BT increase after RBCT. No significant differences in SBF BT were observed after RBCT in different subgroup analyses. Conclusion The skin blood flow is globally unaltered by red blood cell transfusions in non-bleeding critically ill patients after initial resuscitation. However, a lower SBF BT at baseline was associated with a relative increase in skin tissue perfusion after RBCT.