173 publications from this institution
No abstract is provided for this article.
Understanding towards chain-breaking antioxidants as potent inhibitors of lipid peroxyl radicals, high-throughput efforts have been investigated for antioxidant behaviour of 6-bromo-3,3-dimethyl-8 hexadecyltelluro [1,3]dioxepino[5,6-c]pyridin-9-ol and 2-methyl-2,3-dihydrobenzo[b]selenophene-5-ol in the two phase (chlorobenzene/water) lipid peroxidation model system at various pH 1-7 and mild co-antioxidants such as (glutathione, dithiothreitol, ascorbic acid, sodium ascorbate, and potassium hexacyanoferrate(II) trihydrate, sodium metasulfite, and tris(2-carboxyethyl)phosphine hydrochloride). The key chain-breaking mechanism profile was attributed towards the first oxygen transfer atom from the lipid peroxyl radical to the Se/Te atoms and then hydrogen atom transfer from the nearby phenolic group by the alkoxyl radical due to the weak O-H bond dissociation energy in the solvent cage. Finally, the regeneration could take place by the presence of aqueous soluble co-antioxidants that increased the inhibition time of antioxidants more efficiently than α-tocopherol. Tellurium analouge at pH 2-5 in presence of N -acetylcysteine offered better protection for chain-breaking capacity than the selenium analouge. In the presence of aqueous soluble N -acetylcysteine at pH 1-7, both antioxidants in the present study behaved very good inhibitors of lipid peroxyl radicals.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
