514 publications from this institution
The role of the signal sequence in protein export is reviewed, and some difficulties inherent in the conventional picture of how it interacts with other components of the export machinery are pointed out. An alternative model is suggested, which seems to account better for some of the critical experimental findings made so far.
Translocation of proteins through the inner membrane of E. coli is normally catalyzed by the so‐called sec ‐machinery. Yet, many integral inner membrane proteins appear not to require a fully functional sec ‐machinery for proper insertion, in spite of the fact that sometimes quite sizable domains have to be translocated to the periplasmic side. This review will focus on recent studies of sec ‐independent translocation events in an attempt to pin‐point the main differences between sec ‐dependent and sec ‐independent translocation.
