This paper presents a digital power supply controller for variable frequency and voltage circuits. By using a ring oscillator as a method of predicting circuit performance, the regulated voltage is set to the minimum required to operate at a reference frequency which maximizes energy efficiency. Our initial test silicon, implemented with a fixed frequency controller is analyzed and reveals that the controller's power consumption is a major limitation for such a design. To make the controller power dissipation scale with the CV/sup 2/f power of the load, we introduce a new architecture with variable frequency control, which allows the controller's supply and frequency to scale along with the load device.
ABSTRACT We examined the extent to which the scientific workforce in different fields was engaged in publishing COVID-19-related papers. According to Scopus (data cut, August 1, 2021), 210,183 COVID-19-related publications included 720,801 unique authors, of which 360,005 authors had published at least 5 full papers in their career and 23,520 authors were at the top 2% of their scientific subfield based on a career-long composite citation indicator. The growth of COVID-19 authors was far more rapid and massive compared with cohorts of authors historically publishing on H1N1, Zika, Ebola, HIV/AIDS and tuberculosis. All 174 scientific subfields had some specialists who had published on COVID-19. In 109 of the 174 subfields of science, at least one in ten active, influential (top-2% composite citation indicator) authors in the subfield had authored something on COVID-19. 52 hyper-prolific authors had already at least 60 (and up to 227) COVID-19 publications each. Among the 300 authors with the highest composite citation indicator for their COVID-19 publications, most common countries were USA (n=67), China (n=52), UK (n=32), and Italy (n=18). The rapid and massive involvement of the scientific workforce in COVID-19-related work is unprecedented and creates opportunities and challenges. There is evidence for hyper-prolific productivity.
This paper investigates the effect of lowering the supply and threshold voltages on the energy efficiency of CMOS circuits. Using a first-order model of the energy and delay of a CMOS circuit, we show that lowering the supply and threshold voltage is generally advantageous, especially when the transistors are velocity saturated and the nodes have a high activity factor, In fact, for modern submicron technologies, this simple analysis suggests optimal energy efficiency at supply voltages under 0.5 V. Other process and circuit parameters have almost no effect on this optimal operating point. If there is some uncertainty in the value of the threshold or supply voltage, however, the power advantage of this very low voltage operation diminishes. Therefore, unless active feedback is used to control the uncertainty, in the future the supply and threshold voltage will not decrease drastically, but rather will continue to scale down to maintain constant electric fields.
As the scientific enterprise has grown in size and diversity, we need empirical evidence on the research process to test and apply interventions that make it more efficient and its results more reliable. Meta-research is an evolving scientific discipline that aims to evaluate and improve research practices. It includes thematic areas of methods, reporting, reproducibility, evaluation, and incentives (how to do, report, verify, correct, and reward science). Much work is already done in this growing field, but efforts to-date are fragmented. We provide a map of ongoing efforts and discuss plans for connecting the multiple meta-research efforts across science worldwide.
A kinetic inductance memory cell is examined. Such a memory cell can be made small and is more tolerant of the effects of nearby trapped flux than the conventional method of storing data. However, magnetic control of the cell is lost and current injection methods are required to read and write the data. The authors describe a conceptual kinetic inductance nondestructive-read-out memory cell along with a current injection access architecture. A potential fabrication technology that will minimize the size of the memory cells is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human genomics and human nutrition are two very large domains of epidemiological investigation, but their overlap has remained relatively limited to date. Most studies that address genetic risk factors ignore nutritional and other related exposures, and vice versa. Both domains have not only a history of exciting discoveries, but also a tenuous, if not poor, replication record (Ioannidis, 2005a Ioannidis, J. P. 2005a. Why most published research findings are false. PLoS Med., 2: e124[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Ioannidis et al., 2001 Ioannidis, J. P., Ntzani, E. E., Trikalinos, T. A. and Contopoulos Ioannidis, D. G. 2001. Replication validity of genetic association studies. Nat. Genet., 29: 306–309. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). For nutritional and lifestyle epidemiology, randomized trials have failed to confirm a large number of associations proposed by observational data (Ioannidis, 2005b Ioannidis, J. P. 2005b. Contradicted and initially stronger effects in highly cited clinical research. JAMA., 294: 218–228. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). For genetic epidemiology, a major transformation in the last few years has suggested that most candidate gene associations proposed in the past were likely false-positives (Manolio et al., 2008 Manolio, T. A., Brooks, L. D. and Collins, F. S. 2008. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest., 118: 1590–1605. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; McCarthy et al., 2008 McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. and Hirschhorn, J. N. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet., 9: 356–369. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). The new transformation of genetic epidemiology has led to a new mode of discovery and validation of associations based on shear massive testing (large-scale studies on large-scale massive-testing platforms) (McCarthy et al., 2008 McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. and Hirschhorn, J. N. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet., 9: 356–369. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). The list of successfully discovered gene variants that regulate the risk for common diseases continues to grow on a weekly basis (Manolio et al., 2008 Manolio, T. A., Brooks, L. D. and Collins, F. S. 2008. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest., 118: 1590–1605. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). It is worthwhile to examine whether some of the lessons of this recent transformation can also be extended to human nutritional and lifestyle epidemiology. There are clear differences between the genomics and nutrition fields. A major difference is that massive measurement platforms are not yet available for nutritional and lifestyle exposures, at least on the large scale available for genomic markers. Nevertheless massive-scale biochemical measurements and massive collection of electronic information (e.g., through mobile telephones or the Internet) may get closer to achieving the high-throughput paradigm that is currently prevalent in genomics. The correlation pattern between nutritional/lifestyle variables is far denser than the correlation pattern of genomic markers; however, disequilibrium is also considerable in some areas of the genome linkage and poses similar problems in the attribution of causality. In general, markers that arise from genome-wide association studies are only correlates of risk, and may be far from the real causative culprit. Human genome epidemiology has also made major progress by being able to cut down dramatically in measurement error by imposing very strict quality-control standards. The use of rigorous standards also should be feasible in other areas of epidemiological investigation. The need for longitudinal measurements and the unavoidable missing information may be different from genomic epidemiology; however, genomic markers also need to be further validated in longitudinal studies, rather than only the case-control designs that have been relatively successful for genetic epidemiology so far (Wellcome Trust Case Control Consortium, 2007 Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature., 447: 661–678. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Firm documentation of gene-environment interactions will require examination in very large cohorts and biobanks (Elliott et al., 2008 Elliott, P., Peakman, T. C. and the UK Biobank. 2008. The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int. J. Epidemiol., 37: 234–244. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Thus, a new paradigm of extremely large cohorts and coalitions thereof is due to appear. Repeated measurements are also essential for nutritional epidemiology, as opposed to the genotypic information that is standard and fixed at birth. Genomic epidemiology has been more eager to adopt explicit consideration of multiplicity issues, which has led to a more uniform adoption of rigorous standards for what is considered appropriately replicated and credible as an association. Similar improvements must also be made in nutritional epidemiology in which traditional significance levels without any correction are entrenched in the literature. Most associations that are claimed to be significant in traditional epidemiology would have very modest, inconsequential Bayes factors (Ioannidis, 2008 Ioannidis, J. P. 2008. Effect of formal statistical significance on the credibility of observational associations. Am. J. Epidemiol., 168: 374–383. discussion 384–390[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) if viewed from a Bayesian perspective and their credibility would likely be very tenuous. Nutritional and lifestyle epidemiology may also learn useful lessons from the advent and successful application of large international consortia in genomic epidemiology (Seminara et al., 2007 Seminara, D., Khoury, M. J., O’Brien, T. R., Manolio, T., Gwinn, M. L., Little, J., Higgins, J. P., Bernstein, J. L., Boffetta, P., Bondy, M., Bray, M. S., Brenchley, P. E., Buffler, P. A., Casas, J. P., Chokkalingam, A. P., Danesh, J., Davey Smith, G., Dolan, S., Duncan, R., Gruis, N. A., Hashibe, M., Hunter, D., Jarvelin, M. R., Malmer, B., Maraganore, D. M., Newton-Bishop, J. A., Riboli, E., Salanti, G., Taioli, E., Timpson, N., Uitterlinden, A. G., Vineis, P., Wareham, N., Winn, D. M., Zimmern, R. and Ioannidis, J. P. 2007. Human Genome Epidemiology Network; the Network of Investigator Networks. The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology., 18: 1–8. [Google Scholar]) and from the public deposition of data and lack of selective reporting in large-scale genomic databases (Ioannidis, 2007 Ioannidis, J. P. 2007. Molecular evidence-based medicine: evolution and integration of information in the genomic era. Eur. J. Clin. Invest., 37: 340–349. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In summary, it is unlikely that either genes or exposures alone will be able to reveal much about the risk of human diseases. Integrating information on both sides may be essential to making genuine progress. Very large studies that explicitly measure genetic exposures, nongenetic exposures, and outcomes on a massive scale may be a way to make progress, but they present several challenges to be surmounted.
