EDITORIAL article Front. Psychiatry, 03 March 2020 | https://doi.org/10.3389/fpsyt.2020.00103
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system, often leading to poor sleep quality and diminished quality of life (QoL) for affected patients. Sleep disturbances in MS do not always correlate linearly with other symptoms such as anxiety, depression, fatigue, or pain. Various approaches, including stress reduction techniques such as mindfulness-based interventions, have been proposed to manage MS-related sleep issues.
The present study investigates the effect of Electrochemical Manganese Dioxide (EMD) by-product as a replacement of cement, on durability of concrete and the corrosion protection of reinforcement steel. Reinforced cement mortars were partially immersed in 3.5% w. w NaCl solution and they were exposed to atmospheric conditions for a period of 24 months. Additions of 5% and 10% EMD byproduct were tested. The following techniques were used: half-cell potential measurements (HCP), linear polarization Resistance (LPR), mass loss of reinforcement steel, determination of carbonation depth of mortars, testing of compressive strength, total and open porosity measurements. Based on the up-to-now results of this study, the specimens with addition 10% appear smaller corrosion currents and mass loss of steel than reference specimens. Also, the compressive strength with 10% additive is appeared to be slightly higher from the reference specimens.
Approximately 2,500 years ago, at the time of Pericles, a great human civilization peaked in Athens, the city of Athenian democracy. This civilization, which has had a great impact on the modern world, was based on ancient Greek principles, ideas and core values, including moderation, liberty, democracy, justice and the need to use reason to interpret the physical laws of the cosmos. The same civilization founded the sciences as they are known today, initiated evidence‑based medicine, promoted the letters and advanced the fine arts, including drama theatre. Astronomy, mathematics and medicine had already been developed by the Babylonians, Egyptians and others, many centuries before the Greeks. What made the real difference was the development of the field of philosophy and the implementation of its principles in real life (1). Early Greek philosophy related to cosmology was already developed in the pre‑Socratic era, while philosophy regarding the nature of man was initiated by Socrates and further developed by Plato and other Greek philosophers, including Aristotle, Plato's best student, Zeno, the founder of the Stoic School, and Epicurus, the originator of the Epicurean School. At a walking distance from the Acropolis lies Plato's ‘Academy’, one of the most well‑known schools of philosophy in the ancient world. Philosophy was a pivotal creation of Greek civilization and a fundamental achievement of the human mind. If philosophy was what made the difference in the Athenian civilization, can we say that the philosophy of medicine also made a momentous difference in medicine? The answer is: Yes. The Hippocratic Οath is the most significant medical and ethical legacy of Hippocrates of Cos, and its tenets are still pertinent (2). To honour and respect our medical teachers (‘To hold my teacher in this art equal to my own parents'), to forbid practicing euthanasia (‘Neither will I administer a poison to anybody when asked to do so, nor will I suggest such a course’), and to maintain confidentiality of the medical examination (‘Whatsoever I shall see or hear in the course of my profession, as well as outside my profession in my intercourse with other people, I will hold all these to be holy secrets’), are all philosophical ethical principles. Modern Western medicine based on cost‑effectiveness, public and private healthcare insurance systems and limited financial resources, underlines the importance of medical philosophy in the practice of medicine by contemporary health professionals (3). Of course, robust scientific knowledge is a sine qua non of practicing effective medicine; however, without understanding and incorporating the key principles of medical philosophy, health professionals might practice unprincipled, potentially unethical and even damaging medicine. Evidence‑based medicine is also grounded on medical philosophy (4). There is a wealth of medical knowledge, which is essential for the practice of medicine; however, how this knowledge is interpreted and applied is equally or more important. To practice evidence‑based medicine is both a practical and a philosophical decision. Thus, philosophy is a great companion of medicine, as it is of every science or art. In addition, medicine is not just a science, but a combination of science and art, their common goal being alleviating human suffering. Without any doubt, medical education should include the teachings of medical philosophy. Are there currently courses dedicated to the Hippocratic Oath and the ethical principles of medicine included in the medical school curricula? Probably not, at least in a systematic way. The principles of medical philosophy could be taught in an auditorium with lectures and presentations; however, the primary site of such crucial education of medical students and trainees is the bedside, during their direct practice of medicine and ward‑based training (5). Unfortunately, as new knowledge is exponentially increasing, and while time available to medical practitioners is decreasing, the priorities of medical education focus primarily on technical medical knowledge, neglecting its ethical philosophical component. Contemporary teaching frequently highlights endless details from the basic sciences, molecular medicine and the mechanistic pathophysiology of diseases, without distinct teaching as to how to apply this knowledge in the clinical practice in a compassionate and humane fashion (6). Is current teaching of medical philosophy sufficient? Doubtful. What is truly required is the implementation of the principles of medical philosophy in everyday clinical practice. Are the principles easily employed in real life? This is also doubtful. When Plato was due to retire from the leadership of the Academy, he chose Speusippus, his nephew, rather than Aristotle, his best student, as its leader (7). Due to this fact, Aristotle left Athens for Asia Minor and later for the island of Lesbos and the Macedonian city of Pella, where he taught Alexander the Great. Even when he returned to Athens, about 12 years later, and Speusippus had already died, again he was not chosen for the leadership of the Academy. Despite this, in the ensuing years, he founded his own school, the Lyceum, and became known as the greatest philosopher of the ancient Greek world. Plato's example shows us the difficulty that this idealist teacher of philosophy had in implementing his philosophical principles in real life. Plato had described his ideal ‘politeia’ of isonomia and equality, and had talked about the core human virtues, the value of truth, and the need for dialogue. He was always looking for the best in both persons and societies. Unfortunately, however, his decision on his succession may have been based on nepotism. This was in contrast with his teachings, and was interpreted by later scholars as the result of either the strictly enforced Athenian legal policy or the social corruption of the Athenians after the loss of their freedom to the Spartans in the Peloponnesian War (8). The implementation of medical philosophy by health professionals is indeed a difficult, yet essential task. Life principles should not remain theoretical, but instead should be incorporated into real life and applied in everyday clinical practice. The teaching of medical philosophy to health professionals is undoubtedly fundamental, and its implementation in clinical practice is of the highest moral and societal significance. When philosophical principles are properly applied in medicine, clinical practice becomes optimal for the benefit of the practitioner, the patient and society at large.
Hypertension in patients with Cushing's syndrome (CS) occurs in up to 95% of adult and in half of pediatric cases. It represents a major cardiovascular risk and mortality factor in such patients. Its pathogenesis is incompletely understood and includes an imbalance of factors involved in vasodilation and vasoconstriction. Amongst these are upregulation of the renin–angiotensin system activity, salt and water retention, increased peripheral resistance, increase in production/activity of endothelin-1 and vasopressin, increased reactivity to catecholamines, as well as decline in antioxidants, nitric oxide synthase, and others. Patients with ectopic CS usually have more pronounced hypercortisolism and hypertension than patients with CS of other etiologies. This might in part be caused by a functional state of mineralocorticoid excess due to oversaturation of the 11-beta-hydroxysteroid dehydrogenase type 2 enzyme. In patients with exogenous CS, the prevalence of hypertension is dose-dependent and lower (about 20%) than in those with endogenous CS. The aim of therapy is to normalize blood pressure and to remove the source of glucocorticoid excess with subsequent resolution of hypertension after surgical cure which will occur in almost all children and adolescents, but only in two-thirds of adults. This resolution depends on the age of onset, duration, and degree of glucocorticoid excess, as well as other underlying hypertension risk factors such as obesity, sleep apnea, and insulin resistance. Treatment should include ACE inhibitors and angiotensin II receptor blockers, as well as eplerenone in selected patients (especially those with ectopic CS). Glucocorticoid excess and its effects should be controlled, if necessary with careful use of drugs such as steroidogenesis inhibitors or type II glucocorticoid receptor antagonists.
Sex has been universally acknowledged as a confounding factor in every type of biological study, while there are strong sex differences in morbidity along the lifespan. Humans have almost identical genomes (99.2%), yet minor variance in their DNA produces remarkable phenotypic diversity across the human population. On the other hand, metagenomic analysis of the human microbiome is more variable, depending on the sex, lifestyle, geography, and age of individuals under study. Immune responses in humans also exhibit variations, with an especially striking sexual dimorphism, which is at play in several other physiologic processes. Sex steroids have noticeable effects on the composition of the human microbiome along the lifespan, accompanied by parallel changes in immunity and the stress response. Gut microsex/genderome, a recently coined term, defines the sexually dimorphic gut microbiome. Apart from the sex steroids, the stress hormones are also at play in the proliferation of microbes. This review summarizes the concept of gut microsex/genderome under the prism of recent studies on the interrelations of the sexually dimorphic microbiome with immunity and stress.
