SPO2IDA is introduced, a software tool that is capable of recreating the seismic behaviour of oscillators with complex quadrilinear backbones. It provides a direct connection between the static pushover (SPO) curve and the results of incremental dynamic analysis (IDA), a computer-intensive procedure that offers thorough demand and capacity prediction capability by using a series of nonlinear dynamic analyses under a suitably scaled suite of ground motion records. To achieve this, the seismic behaviour of numerous single-degree-of-freedom (SDOF) systems is investigated through IDA. The oscillators have a wide range of periods and feature pinching hysteresis with backbones ranging from simple bilinear to complex quadrilinear with an elastic, a hardening and a negative-stiffness segment plus a final residual plateau that terminates with a drop to zero strength. An efficient method is introduced to treat the backbone shape by summarizing the analysis results into the 16, 50 and 84% fractile IDA curves, reducing them to a few shape parameters and finding simpler backbones that reproduce the IDA curves of complex ones. Thus, vast economies are realized while important intuition is gained on the role of the backbone shape to the seismic performance. The final product is SPO2IDA, an accurate, spreadsheet-level tool for performance-based earthquake engineering that can rapidly estimate demands and limit-state capacities, strength reduction R-factors and inelastic displacement ratios for any SDOF system with such a quadrilinear SPO curve. Copyright © 2006 John Wiley & Sons, Ltd.
Sex-related differences in the stress response are well described in the animal literature but in humans are inconsistent and appear to reflect both the method used to stimulate the hypothalamic-pituitary-adrenal (HPA) axis and the age of the subjects. Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity.The aim of this study was to address this role independent of differences in reproductive steroid levels. We compared HPA axis response to pharmacological (CRH) and physiological (exercise) stressors in two groups of young to middle-aged (18-45 yr) men (n = 10 and 8) and women (n = 12 and 13) undergoing gonadal suppression with leuprolide acetate (monthly im injection of 7.5 mg in men and 3.75 mg in women).Exercise and CRH stimulation tests were performed during induced hypogonadal conditions.The study was conducted at a National Institutes of Health Clinical Center Outpatient Clinic. PATIENT OR OTHER PARTICIPANTS: Male and female normal volunteers participated in the study.The main outcome measures were stimulated ACTH and cortisol levels.Both CRH (1 microg/kg) stimulation and graded treadmill exercise stimulation occurred in the month after the second leuprolide injection to ensure gonadal suppression. Despite the absence of sex differences in estradiol or testosterone at the time of testing, men showed increased stimulated ACTH (repeated-measures ANOVA for CRH, P < 0.005) and cortisol (repeated-measures ANOVA for exercise, P < 0.05) compared with women. Among the summary measures, area under the curve (AUC) for cortisol was significantly greater in men than women after exercise. Although the AUC for ACTH was not significantly different across sexes, the initial AUC (0-30 min) was significantly greater in men for both procedures. No significant sex differences were found in a measure of adrenal responsivity, the cortisol to ACTH ratio, for either procedure. Cortisol-binding globulin levels did not differ between men and women and were not correlated with stimulated HPA axis measures. These data confirm earlier reports of sex differences in stimulated HPA axis activity and demonstrate that these differences exist even under induced hypogonadal conditions (i.e. in the absence of characteristic differences in reproductive steroids).
The continuous 24-h infusion of a maximally stimulating dose (1 micrograms/kg per h) of ovine corticotropin-releasing factor (CRF) in man caused a modest elevation of plasma cortisol (17.2 +/- 1.4 micrograms/dl) and urinary-free cortisol (173 +/- 43 micrograms/24 h) concentrations, which was far less than that seen with a maximally stimulating dose of ACTH (50.4 +/- 2.2 micrograms/dl and 1,200 +/- 94 micrograms/24 h, respectively). The circadian rhythms of plasma ACTH and cortisol were preserved during CRF administration. An intravenous bolus injection of 1 microgram/kg of ovine CRF given to normal volunteers under basal conditions resulted in elevated plasma ACTH and cortisol peak levels (28 +/- 6 pg/ml and 15.0 +/- 1.0 micrograms/dl, respectively). However, no plasma ACTH and cortisol responses were observed when an identical CRF stimulation test was given at the end of the continuous infusion. These findings suggest that the stimulatory activity of exogenous CRF on the ACTH-secreting cells of the pituitary gland is restrained by the negative feedback of cortisol. The persistent circadian rhythm of ACTH, despite a constant level of plasma CRF during the infusion, suggests that the circadian variation in the activity of the hypothalamic-pituitary-adrenal axis cannot be explained solely by circadian periodicity of the endogenous CRF stimulus.
To facilitate the logistic processes within a modern warehouse, the contents of steel racking systems are not mechanically connected to the supporting beams, allowing a content‐sliding mechanism to develop when static friction is exceeded. Given that the mass of contents is dominant, this is beneficial for limiting the apparent inertia. On the other hand, pallet fall‐off may occur during strong seismic excitations, which is a failure mode that is not addressed by current seismic design processes and guidelines for racks. Along these lines, a codifiable methodology is proposed for estimating sliding displacements on steel racking systems, based on the statistical interpretation of a large set of response history analyses, using different rack configurations and ground motions. Firstly, a multi‐parametric analysis is conducted using simplified rack models to (i) select the intensity measure and engineering demand parameter that can best describe the problem of pallet sliding and (ii) identify the salient rack characteristics that dominate sliding behavior. Thereafter, a series of multi‐stripe analyses are performed using 180 rack realizations with different feature combinations to derive a so‐called, Empirical Sliding Prediction Equation (ESPE) by following a three‐step procedure: (a) perform regression on maximum sliding, (b) perform regression on the normalized sliding profile, and (c) combine steps a‐b to derive the denormalized profile at a given confidence level. The proposed empirical relationships are then validated through a comparison between the observed and fitted sliding displacements in three rack case studies.
Summary Several proposals are explored for the hazard and intensity measure (IM) consistent selection of bidirectional ground motions to assess the performance of 3D structural models. Recent studies have shown the necessity of selecting records that thoroughly represent the seismicity at the site of interest, as well as the usefulness of efficient IMs capable of estimating the response of buildings with low scatter. However, the advances realized are mostly geared towards the structural analysis of 2D models. Few are the combined record, and IM selection approaches suggested expressly for nonlinear dynamic analysis of 3D structural models, especially when plan asymmetry and torsion sensitivity come into play. Conditional spectrum selection is leveraged and expanded here to offer a suite of approaches based on both scalar and vector IMs that convey information from two orthogonal horizontal components of the ground motion. Applications on multiple 3D building models highlight the importance of (a) employing the same IM for both record selection and response assessment and (b) maintaining hazard consistency in both horizontal components, when using either a scalar or a vector IM. All tested approaches that respect these conditions can be viable, yet the one based on the geometric mean of multiple spectral ordinates from both components over a period range seems to hold the most promise for general use.
