4,552 publications from this institution
The rate of sister chromatid exchange induced by several anti-herpes agents was measured to assess their potential mutagenicity. The agents--5-iodo-deoxyuridine (IDU), 5-trifluoromethyl-deoxyuridine (TFT), and [E]-5-(2-bromovinyl)-deoxyuridine (BVDU)--were incubated at various concentrations with human lymphocytes and fibroblasts, and that rate of sister chromatid exchanges was measured. In lymphocytes and fibroblasts BVDU and IDU did not induce exchange except at concentrations of 50 mg/l, while TFT increased the rate of exchange at a concentration of 0.5 mg/l. The rate of sister chromatid exchange is a sensitive index of chromosomal damage, and these findings provide information on the safety of some of the antiherpes agents tested. TFT increased the rate of exchange at a concentration that coincides with its minimal antiviral concentration, but BVDU did not induce exchange at therapeutic concentrations.
Using CMMs under normal workshop conditions necessitates to take into account the influence of environmental temperature on the machine structure. Non-standardised environmental conditions result in temperature dependent measurement errors. The paper presents a parametric approach to describe the relation between transient temperature distributions and resulting deformation of the CMM. The focus lies on broadening the temperature range in which the original accuracy specifications can be guaranteed. Starting from a correction scheme for uniform, invariant temperature situations, an approach for transient environmental loads is developed. Based on a limited number of temperature inputs, the required correction coefficients for the probe position are calculated.
Differential Effects of E-5-(2-Bromovinyl)-2'-Deoxyuridine on Infections with Herpes Simplex Virus Type 1 and Type 2 in Hairless Mice Erik De Clercq, Erik De Clercq ega Institute for Medical Research Katholieke Universiteit Leuven, Leuven, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Zhen-Xi Zhang Zhen-Xi Zhang ega Institute for Medical Research Katholieke Universiteit Leuven, Leuven, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 145, Issue 1, January 1982, Page 130, https://doi.org/10.1093/infdis/145.1.130 Published: 01 January 1982
No abstract is provided for this article.
Several polyanionic compounds were found to suppress intracutaneous infection of hairless mice with herpes simplex virus type 2 (HSV-2) only when present at the time of inoculation. Because (a) sexual intercourse is a major route of infection with human immunodeficiency virus (HIV); (b) due to the species-specificity of HIV, there is no small animal model to study intra-vaginal HIV infection; (c) HIV is equally or even more sensitive than HSV-2 to several polyanions; and (d) sulfated polymers may prevent the adhesion of (HIV-infected) lymphocytes to epithelial cells, we evaluated the effect of the compounds on intravaginal infection of mice with HSV-2. To this end, mice were infected intravaginally with a virus-compound mixture. Under the conditions used, the polysulfate dextran sulfate conferred only partial protection against infection and virus-induced mortality. However, PAVAS (a co-polymer of acrylic acid with vinylalcohol sulfate) completely protected against the infection. These results should be taken into account when planning clinical studies with a vaginal polysulfate formulation for the prevention of sexually transmitted HIV and/or HSV-2 infections.
In this paper, the authors propose an erosion index for wire materials or wire coatings. In sinking EDM research and practice, an erosion index is commonly available. In wire EDM few efforts have been made to identify possible electrode materials from the point of view of cutting speed. The index is based on physical understanding of the process and uses thermal properties of the electrode material, as is the case for the sinking EDM erosion index. The most important materials used as a coating for wire electrodes, like Zn, Cu, W and Mo, are analyzed and the proposed index is in good correlation with experimental cutting data, both from literature reports and own experiments. The theory can also be applied to alloys, such as brass (Cu-Zn) with different amounts of zinc.
