Publications

Reverse engineering of free-form surfaces from point clouds subject to smoothness conditions

Selective laser melting towards manufacture of three dimensional in situ Al matrix composites : A review

Selective laser melting towards manufacture of three dimensional in situ Al matrix composites : A review

Bovid herpesvirus type-1 (Infectious bovine rhinotracheitis virus) induced thymidine kinase

A Computer Integrated Machining Strategy for Planetary EDM

In order to optimize planetary EDM, an appropriate machining strategy was defined and implemented using a micro computer. The strategy calculates and adapts on-line the pulse current and the discharge duration based on a continuous measurement of the eccentricity. A number of independent sectors on the planetary orbit were defined. The generator settings that are to be applied in a sector are calculated one turn of the planetary orbit in advance. A machining time gain of about 50% could be observed for a cylindrical electrode. Alternative planetary motions are investigated to overcome some specific problems related to the circular planetary motion. It is proposed to combine the circular orbit with a lateral uni-directional machining mode in function of an on-line form recognition of the planetary orbit. This planetary motion is introduced in the machining strategy, yielding an additional time gain of about 30% for a rectangular electrode

Ebola virus (EBOV) infection: Therapeutic strategies

ChemInform Abstract: Prodrugs of 5‐Ethyl‐2′‐deoxyuridine. Part 2. Syntheses and Antiviral Activities of 5′‐ and 3′‐Ester Derivatives.

Abstract Die 3′‐Acylderivate der Desoxyuridine (IV) werden auf dem angegebenen Wege synthetisiert und im Vergleich mit den 5′‐Acylderivaten (V) auf antivirale Eigenschaften (HSV‐1) untersucht.

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

A PROSA architecture for machine tool control

Novel Potential Agents for Human Cytomegalovirus Infection:  Synthesis and Antiviral Activity Evaluation of Benzothiadiazine Dioxide Acyclonucleosides

The first acyclonucleosides based on the benzothiadiazine dioxide system were synthesized following the silylation procedure. Several acyclic moieties, including acetoxyethoxymethyl, benzyloxymethyl, and propargyloxymethyl groups, were introduced. Two synthetic strategies were designed to selectively obtain the N-1 or N-3 derivatives. Lipase-mediated deacylation was used for the deprotection of the acyclonucleosides. Some of the benzothiadiazine dioxide acyclonucleosides, in particular 16, proved active against human cytomegalovirus (CMV) at concentrations slightly higher than that found for ganciclovir [50% inhibitory concentration (IC50) = 3. 5-3.7 micrograms/mL, cytotoxicity (CC50) >/= 40 micrograms/mL, MCC = 20 micrograms/mL]. Additionally, compound 16 inhibited the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in CEM cells at concentrations that were 5-fold lower than its cytotoxic concentration.

Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs

Abstract Several 2′,3′-dideoxynucleosides have proven to be effective against HIV-1 in cell culture. The 2′,3-unsaturated analogues dideoxycytidinene (D4C) and dideoxythymidinene (D4T) are among the most potent and selective inhibitors of HIV-1 replication in vitro. However, 2′,3′-didehydro-2′,3′-dideoxynucleosides are relatively unstable. A chlorine substituent at the 2′-position increases the stability, and, therefore, some 2′-chloro-2′,3′-didehydro-2′,3′-dideoxynucleosides were synthesized and evaluated for anti-HIV-1 activity.

Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles

The emerging challenge of HIV-1 drug resistance urgently demands the development of next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Herein, we designed and synthesized two series of novel 2,4,6-trisubstituted pyrimidines that target a previously insufficiently explored binding site at the interface between the p66 and p51 subunits of HIV-1 reverse transcriptase (RT). After iterative structural optimization, <b>15k</b> turned out to exhibit potent antiviral activity to wild-type and mutant HIV-1 strains, with EC₅₀ values ranging from 0.0046 to 0.033 μM and relatively low cytotoxicity (CC₅₀ = 26.64 μM). Molecular modeling revealed that <b>15k</b> adopts a unique "Y-shaped" conformation within the NNRTI-binding pocket (NNIBP), forming novel hydrogen bonds with E138 and K101 at the p51-p66 interface─a key factor contributing to its potent resistance profile. Moreover, <b>15k</b> exhibits favorable <i>in vivo</i> metabolic (<i>T</i>_1/2 = 2.12 h) and safety profiles. In summary, newly discovered <b>15k</b> represents a promising anti-HIV-1 drug candidate for further development.

Fast interference verification for sheet metal bending operations

An Operation Planning System for Multi-Axis Milling of Sculptured Surfaces

CCDC 192103: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Generierende, schichtweise Herstellung von Werkstücken und Werkzeugen aus Metallen 3D-Erfahrungsforum Werkzeug- und Formenbau

No abstract is provided for this article.

Mobilité, transports et psychologie : un champ disciplinaire à construire ?

Présentation du dossier sur la psychologie des transports et de la conduite dans le Journal des Psychologues

Direct Digital Manufacturing of Complex Dental Prostheses

'Direct Digital Manufacturing of Complex Dental Prostheses' published in 'Bio-Materials and Prototyping Applications in Medicine'

CMM Sensor Evaluation Method with Machine Error Exclusion