Publications

The high-temperature behaviour of micro-crack free Hastelloy X produced by SLM has been studied. The microstructure and mechanical behaviour of as-built parts and heat-treated (at 1177 and 800 °C) parts were investigated. Quasi-static tensile tests were performed at room temperature and elevated temperatures (650, 750 and 850 °C) for the three heat treatment conditions. In order to better understand the tensile test performance, the microstructure evolution of as-built samples as function of temperature was studied using confocal scanning laser microscopy (CSLM). CSLM allows in situ observation of the microstructure evolution while the sample temperature is increased. During tensile testing, a significant decrease in tensile strain was observed at a testing temperature of 750 °C that was attributed to the precipitation of carbides and Mo-rich intermetallic phases, as observed during and after CSLM. The samples heated at 1177 °C showed less carbide formation due to their more homogeneous starting microstructure, which resulted in a tensile ductility increase as compared to the as-built and 800 °C heat-treated samples.

The development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosterism principle, two novel 2-(5-(naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides derivatives have been designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. The results indicate that these compounds show good activities against HIV-1. Especially, compound 9B (EC50 = 0.019 μM) was more effective than the reference drugs nevirapine and delavirdine.

Abstract The advent of AIDS has prompted the search for effective anti-HIV-1 agents, and, in view of the efficacy of azidothymidine in the treatment of AIDS, 2′,3′-dideoxynucleosides and analogues thereof have been considered as the most obvious candidates for AIDS chemotherapy. Various substituents have been introduced at the 3′-position, but only the 3′-azido and 3′-fluoro derivatives were found active against HIV-1. Introduction of a fluorine in organic compounds frequently causes a dramatic change in their biological activity. The stability of the carbon-fluorine bond and the strong electronegative character of fluorine, altering the electronic properties of the substituted molecule, led us to synthesize dideoxynucleosides with a fluorine substituent at different positions. The synthe-

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Abstract Cycloaddition of different acetylenic compounds on the azido function of 3′‐azido‐2′,3′‐dideoxythymidine and 3′‐azido‐2′,3′‐dideoxyuridine afforded products with a 1,2,3‐triazol‐1‐yl substituent in the 3′‐position. In contrast with the parent compounds, these triazolyl derivatives had no appreciable activity against human immunodeficiency virus (HIV‐1).