Publications

A new series of 6-substituted purinylcarbonucleosides derivatives of indan, 8a-g and 10a-d, was synthesized from (±)-cis-1,3-indandimethanol acetate (5), which was prepared in three steps from benzonorbornadiene. 6-Chloropurine was introduced both by Mitsunobu reaction with 5 and by substitution of the mesylate 6. Suzuki-Miyaura reactions of the protected 6-chloropurine derivative 7 with substituted phenylboronic acids afforded 9a-d (protected purine derivatives with substituted phenyl rings at position 6); deprotection of the latter yielded the new series of purinylcarbonucleoside indan derivatives 10a-d. Treatment of compound 7 with R′H/NaOH afforded a parallel series 8a-g, with alkoxy or amino groups R′ at position 6 instead of substituted phenyl rings.

The title compounds 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4 H )-ones were synthesized by the cyclization of 2-hydrazino-3-phenylquinazolin-4(3 H )-one with various one carbon donors. The starting material 2-hydrazino-3-phenylquinazolin-4(3 H )-one was synthesized from aniline. Investigation of antimicrobial activity of the test compounds was made by agar cup-plate method against 8 pathogenic bacteria including Mycobacterium tuberculosis , 3 pathogenic fungi and antiHIV activity against replication of HIV-1(IIIB) and HIV-2(ROD) in MT-4 cells. The compound 7e inhibited 21% growth of M. tuberculosis at 6.25 µg/ml concentration, while the compounds 7c and 7d showed good antifungal activity against Candida albicans ; and the compounds 7c exhibited good antifungal activity against Aspergillus niger .

New generation of selective Laser Melting (SLM) machines are evolving towards higher power lasers as well as multi laser systems in order to increase the productivity. The increase in laser power and the modification of the laser power distribution leads to microstructural and mechanical property variations that are still not well understood. This work aims at better understanding the interaction of a 1 kW top-hat power distribution laser on a well know material, 316 L stainless steel. The influence of texture and microstructure on relative density and crack density, when varying scan rotation, was evaluated. The high power (HP) laser and low power (LP) laser were compared with respect to microstructure and mechanical properties. HP leads to an increase in morphological and crystallographic texture together with a coarsening of the cell structure in contrast to the more random and finer cells found in LP processed material. Hot isostatic pressing was applied as a post-process treatment in order to close remaining pores and cracks. This helped in achieving higher elongations for LP and HP processed materials, while competitive mechanical properties to the 316 L material specifications were obtained in both cases.

No abstract is provided for this article.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

A series of sulfonic acid polymers were shown to be potent and selective inhibitors of respiratory syncytial virus (RSV) and influenza A virus. The compounds inhibit the replication of RSV and influenza A virus in HeLa and MDCK cells, at concentrations of 0.16 and 4.0 micrograms/ml, respectively, and are nontoxic to growing cells at concentrations of > 100 micrograms/ml. The mode of antiviral action of the sulfonic acid polymers can be ascribed to inhibition of virus-cell fusion (for influenza A virus) or inhibition of both virus-cell binding and fusion (for RSV). The sulfonic acid prototype PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)], when administered intranasally to mice as a single dose of 10 or 50 mg per kg of body weight at the time of infection, completely inhibited influenza A virus replication (in lungs) and virus-associated lung consolidation in immunocompetent mice and completely protected NMRI and SCID (severe combined immune deficiency) mice against influenza A virus-associated mortality. When administered 1 h before or after virus inoculation, no protective effect was observed at a dose of 10 or 100 mg/kg. Sulfonic acid polymers exert selective inhibitory effects on RSV and influenza A virus replication.

No abstract is provided for this article.