4,552 publications from this institution
Journal Article Bis-DEAE-Fluorenone: Mechanism of Antiviral Protection and Stimulation of Interferon Production in the Mouse Get access Erik De Clercq, Erik De Clercq From the Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas C. Merigan Thomas C. Merigan From the Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 123, Issue 2, February 1971, Pages 190–199, https://doi.org/10.1093/infdis/123.2.190 Published: 01 February 1971 Article history Received: 16 July 1970 Revision received: 21 September 1970 Published: 01 February 1971
Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.
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Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.
