168 publications from this institution
The temperature change, internal pressure and corrosion are main reason of cracksin pipes. Removal of damaged pipes with new ones gives rise to major disruptionduring operation. This causes loss of time and cost. This study aims to prevent crackpropagation and to obtain fast repair in damaged area, at the beginning of the dam-age. Repair of small cracks in steel pipes using composite patches has been studiedin this work. The aim of the study is to repair small cracks less than 8 mm length.For this purpose, holes with 8 mm diameters were drilled in 170 mm long pipes andcomposite patches with 2, 2.6 and 3.2 mm thickness and 35, 40 and 45 mm overlaplengths with 60, 90 and 120o overlap angles were attached with an adhesive of0.2 mm thickness. The repaired pipes were subjected to internal pressure until dam-age occurred. A finite element model was developed and the numerical results wereverified based on experiments. The repair of steel pipe with adhesive bonding wassuccessfully achieved under high pressure with composite patches.The results show that the increase in overlap angle results in an increased sur-face area, and consequently an increase in failure load. Furthermore, the failure loadincreased with an increase in patch thickness. Additionally, it is seen that the failureload does not change significantly with increasing patch thickness.
Human health and illness are dependent on lipases, which play a key role in maintaining cell integrity, storing fat for energy and serving as signaling molecules. In this study, 4 compounds that carry 6-phenylpyridazin-3(2H)-one main nucleus, which can be effective as lipase inhibitors, were synthesized and their structures were elucidated. The biological activity of synthesized compounds was evaluated via the porcine pancreatic lipase type II (PLL) inhibitor assay. Orlistat, a lipase inhibitor, was used as a positive control. Compound 8d was found to be the most effective compound, with an IC50 value of 32.66±2.8265 (μg/mL). In addition, molecular docking and molecular dynamics simulations studies were carried out to examine the interactions of the compounds with the target in detail. The results obtained as a result of these in silico studies were found to be compatible with the lipase inhibition effects of the compounds. It was observed that the compounds may have potential lipase inhibitory effects as a result of the substitutions of the 3-(6-oxo-3-phenylpyridazin-1(6H)-yl)propanehydrazide structure.
