169 publications from this institution
Turkey is located on a seismically active region. The active fault zones, primarily the North Anatolian Fault and East Anatolian Fault, constitute a center to the movements. On 24 January 2020 at local time 20:55, an earthquake of Mw = 6.8 struck Sivrice, Elazığ located in eastern part of Turkey. After this main shock, 1185 aftershocks were recorded until February 8, 2020. The main event resulted in 41 human casualties and 1632 injured. Also, 45 people were salvaged from the debris. The earthquake mostly affected to Elazığ and Malatya provinces. 633 buildings were demolished, 10492 buildings were severely damaged, 2161 buildings were moderately damaged, and 16046 buildings were slightly damaged in the affected region. This paper focus on evaluating the damages and failures of masonry, adobe, and historical structures in the affected areas around Elazığ and Malatya provinces.
Abstract Ferrochrome slag (FS) and ground granulated blast furnace slag (GGBFS) were used as resource material in geopolymer concrete mixtures. A mixture of 10 M sodium hydroxide (NaOH) and sodium silicate (Na 2 SiO 3 ) was used as the activator. After the two different slag‐based geopolymer concrete (SGC) mixtures were prepared and molded. They were kept at 80°C for 24 hr, and then the SGC samples were cured in 23 ± 1°C water for 27 days. Samples that completed the curing times were exposed to the 300 freeze–thaw (F–T) cycles. The compressive strength, ultrasonic pulse velocity, relative dynamic elasticity modulus values, weight changes, and appearances of the SGC samples were examined at the end of every 50 F–T cycles. Scanning electron microscopy analysis was performed to examine the microstructure changes of the samples after 300 F–T cycles. As the GGBFS proportion in the SGC mix increased, the mechanical properties of the samples against the F–T effect increased. Samples containing 100% FS and 75% FS fell apart at the end of 150 and 200 F–T cycles, respectively. The deterioration of the geopolymer gel structures of the samples exposed to F–T was decreased with increasing GGBFS ratio in the mix.
Bu çalışmada, kayısı işletmelerinin tedarikçi değerlendirme sürecinde dikkate alması gereken kriterleri ve bunların önceliklerini belirlemeye yönelik bir araştırma gerçekleştirilmiştir. Bu amaçla sektör raporları incelenmiş, uzmanlarla ve kayısı işletmelerdeki tedarik sorumluları ile görüşülmüştür. Elde edilen veriler ışığında olası ana kriterler, kalite-kontrol, fiyat, hijyen, mekanizasyon ve üretim performansı başlıkları altında gruplandırılmıştır. Fiyatta 6, kalitede 10, hijyende 4, mekanizasyonda 6 ve üretim performansında 8 alt kriter olmak üzere toplamda 34 kriter belirlenmiştir. Belirlenen temel ve alt kriterler bulanık mantık çerçevesinde ağırlandırılmış ve sıralanmıştır.
Background: Brain cancer (neuroblastoma) and liver cancer (hepatocellular carcinoma) are common cancer types among others worldwide which do not have a radical treatment and cure. Objective: In the current study, five novel pyridazinone derivates bearing benzelhydrazone moiety at second position were synthesized and evaluated for their cytotoxic activity against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. The aim of the current study is to identify antiproliferative activity of five novel pyridazinone derivates against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. Method: The compounds were synthesized by the reacting 6-[4-(phenyl/4-chlorophenyl)piperazine-1- yl]-3(2H)-pyridazinone-2-yl acetohydrazide with benzaldehyde in ethanol. The in vitro antiproliferative activities were determined with MTT assay. Bax, Bcl-2 and Casp3 gene expression levels were detected with RT-PCR analyses. Results: The lowest IC50 was observed for compound 4 in SHSY5Y and HEP3B cells. Apoptosis increased in cancer cells which was shown by changes inBax, Bcl-2 and Casp3 gene expression levels with 1-5 compound therapy. Conclusion: Novel pyridazinone derivates might be promising agents as new chemotherapeutic candidates in brain and liver cancer. Keywords: Apoptotic effects, antitumoral effects, brain cancer, cytotoxic effects, liver cancer, pyridazinone.
Background: Epigenetic mechanisms play a pivotal role in the transcriptional programs associated with cardiovascular disease (CVD). Apabetalone, an orally available inhibitor of BET proteins that serve as key epigenetic readers, and modulating gene expression - holds promise as a therapeutic intervention in CVD management. Understanding its efficacy and tolerability is crucial for delineating its potential impact on disease progression and patient outcomes. Purpose: This systematic review and meta-analysis aimed to assess the impact of apabetalone in patients with cardiovascular disease. Methods: The meta-analysis was registered with PROSPERO (CRD42023423298). Databases searched included Cochrane CENTRAL, PubMed, Ovid Medline, and Web of Science. Three unique RCTs with total of 2897 patients were included, with trial durations ranging from 12 to 124 weeks. Primary outcomes assessed were all-cause mortality and non-fatal myocardial infarction (MI). Data analysis was performed using the inverse variance common effect model. Subgroup analyses were conducted based on the presence of atherosclerotic cardiovascular disease (ASCVD) or its increased risk. Results: Among the primary outcomes, no significant effects of apabetalone were observed on all-cause mortality (RR 0.88, 95% CI 0.63 to 1.23) or non-fatal MI (RR 0.83, 95% CI 0.62 to 1.11). Apabetalone demonstrated favorable effects on increasing Apo A1 (SMD 0.20, 95% CI 0.04 to 0.35) and HDL (SMD 0.29, 95% CI 0.09 to 0.49). However, no significant effects were observed for changes in Apo B, LDL, non-HDL, total cholesterol. Subgroup analysis did not reveal any significant differences in outcomes. Significant effects were noted in secondary outcomes. Apabetalone showed a significant increase in adverse events (AEs) leading to withdrawal (RR 1.61, 95% CI 1.21 to 2.15) and ALT and AST increases greater than three times the normal value (RR 4.50, 95% CI 2.73 to 7.41). Conclusion: Our meta-analysis highlights the significant impact of apabetalone on certain lipid parameters and adverse events. However, it did not demonstrate significant effects on all-cause mortality or non-fatal MI. Further well-designed and reported RCTs were warranted to elucidate the clinical implications of apabetalone in selected group of patients that might benefit the most from apabetalone that may also improve cardiovascular disease management.
High-strength concrete (HSC) has undergone many developments based on the studies of influence of cement type and cement dosages, type and proportions of mineral admixtures, type of superplasticizer, and the mineralogical composition of coarse aggregates. Most studies were carried out using natural sand. In practice, lightweight aggregates from various sources are frequently used in concrete. In the study, concrete mixtures with varying expanded perlite aggregate (EPA) ratios were subjected to dry and wet curing conditions. The variables for the mixtures were 0, 7.5, 15, 22.5, and 30% EPA ratios, in replacement of fine aggregate, in dry and wet curing conditions. The 28-day compressive strengths varied from 40 to 57 and 54 to 81 MPa for dry and wet curing conditions, respectively. The research results show that both EPA ratios and dry curing condition induced the reductions in compressive strength. The reductions due to the dry curing condition were 30, 33, 35, 40, and 26% for 0, 7.5, 15, 22.5, and 30% EPA ratios, respectively. EPA ratios of 0, 7.5, 15, 22.5, and 30% also reduced compressive strengths of 11, 12, 17, and 33% for wet cured samples. The results also show for the mixtures developed in the study that up to a total EPA content of 30% is able to provide HSC for wet curing condition and only 7.5% EPA is also adequate to achieve the HSC threshold, 50 MPa, in dry curing condition. In addition, ultrasound pulse velocity (UPV), thermal conductivity, and oven dry density of samples at both wet and dry curing conditions were determined, and relationship between thermal conductivity and oven dry density, compressive strength, and UPV were exponential for both wet and dry curing conditions.
It is known that internet have been widespread in many areas of life and enabled machines to communicate each other. The terms of Internet of Things (IoT) has emerged as a result of networks consist of machines and equipment that work independent of operator and communicate each other. Sensors, embedded systems, communication technologies and data storage systems like clouds create wide area networks that can communicate and share data. In this study, the application of the IoT on a low speed mechanical benchmark driven by a direct current motor has been designed. It is aimed to keep the motor speed fixed at desired value according to the changings occurs depending on varying the pressure acting on the actuators. In presented study, a speed control is performed by establishing a modeling and simulation mechanism that will give the closest results to the real system.
I
 n this study, four new oxime ether derivatives were synthesized and their antimicrobial activities were evaluated. At the
 same time, a comparison of the efficiency of the conventional method of synthesis with the microwave method was investigated. The structures of synthesized compounds were confirmed by their IR, 1H-NMR, and HRMS spectra. Antimicrobial
 activity of the compounds was tested against two Gr (+) bacteria (S. aureus, E. faecalis), two Gr (-) bacteria (P. aeruginosa, E.
 coli), and three yeast-like fungi (C. albicans, C. krusei, C. parapsilosis) by modified agar dilution method.
concrete strength levels, namely, of 25 and 40 MPa. Load-displacement curves, energy absorption capacities, stiffness degradation, the moment-curvature relationship, the plastic hinge mechanism and the ductility index were experimentally obtained at two different concrete types along with the measured stress-strain properties of the conventional and perlite concrete. The test results showed that the construction of the RC columns using only perlite may become possible in future by providing an adequate concrete stress-strain capacity, which will be improved.
Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurring inflammation in the colon. Various treatment options are available, but there remains a need for effective therapies that can induce and maintain remission. Ozanimod, a selective sphingosine 1-phosphate receptor modulator, has shown promise in the treatment of UC. This meta-analysis aims to evaluate the effect of ozanimod on induction and maintenance of remission in patients with UC through available randomized controlled trials (RCTs). Methods: A comprehensive literature search was conducted in electronic databases including PubMed, Ovid Medline, Web of Science, Scopus, and Cochrane Library, from inception to April 1, 2023. RCTs evaluating the efficacy and safety of ozanimod in patients with UC were included. Data on study characteristics, patient demographics, intervention protocols, and outcomes were extracted. Risk of bias assessment was performed using the Cochrane RoB2 tool. Meta-analysis was conducted using a random-effects model to calculate pooled estimates of efficacy outcomes. Subgroup analysis was also performed. Results: Two RCTs with 842 UC patients were included. Ozanimod significantly improved clinical remission (RR: 2.97, 95% CI: 1.80-4.90, P< 0.01), clinical response (RR: 1.75, 95% CI: 1.42-2.15), histologic healing (RR: 2.34, 95% CI: 1.52-3.63), and mucosal healing (RR: 3.13, 95% CI: 1.87-5.23) during induction therapy. In maintenance therapy, ozanimod showed benefits in maintaining clinical remission (RR: 2.09, 95% CI: 1.54-2.84, P< 0.01), clinical response (RR: 1.55, 95% CI: 1.30-1.86), histologic remission (RR: 2.24, 95% CI: 1.62-3.10), and mucosal healing (RR: 2.21, 95% CI: 1.58-3.09). Subgroup analysis confirmed ozanimod's efficacy regardless of prior anti-TNF use, disease location, corticosteroid use at screening, or baseline partial Mayo score. However, there were trends suggesting that ozanimod may be particularly beneficial in patients who were naive to prior anti-TNF therapy, had left side disease involvement, or did not use corticosteroids at screening. Common adverse events included nasopharyngitis, serious infections, and upper respiratory infections. Infrequent serious adverse events were comparable in both arms. Conclusion: This meta-analysis supports ozanimod's efficacy and safety in UC remission induction and maintenance, highlighting its therapeutic potential. Further large-scale RCTs are needed for confirmation and expansion of these findings (Figure 1).Figure 1.: Effect of Ozanimod on Induction of Clinical Remission by Subgroup Analysis.
A total of four reinforced concrete (RC) columns were tested to compare the structural capacities of RC columns produced by natural perlite aggregates and conventional concrete. The structural performance of the RC columns made from natural perlite aggregates was compared to conventional RC columns regarding the same concrete strength levels, sectional properties, and reinforcement layouts of conventional RC columns. The RC columns were tested under a combined constant axial load ratio of 30% with cyclic loading for two concrete strength levels, namely, 25 and 40 MPa. Load–displacement curves, energy absorption capacities, stiffness degradation, the moment-curvature relationship, the plastic hinge mechanism, and the ductility index were experimentally obtained at two different concrete types along with the measured stress–strain properties of the conventional and perlite concrete. The test results showed that the construction of the RC columns using only perlite may become possible in the future by providing an adequate concrete stress–strain capacity, which will be improved. Additionally, the use of natural perlite aggregates can contribute to sustainable construction practices by reducing the reliance on conventional aggregates.
Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC50 value of 0.013 µM, followed by T3 (IC50 = 0.039 µM). Inhibitory potency for MAO-B was more enhanced by meta bromo substitution (T6) than by para bromo substitution (T7). For para substitution, inhibitory potencies for MAO-B were as follows: -Cl (T3) > -N(CH3)2 (T12) > -OCH3 (T9) > Br (T7) > F (T5) > -CH3 (T11) > -H (T1). T6 and T3 efficiently inhibited MAO-A with IC50 values of 1.57 and 4.19 µM and had the highest selectivity indices (SIs) for MAO-B (120.8 and 107.4, respectively). T3 and T6 were found to be reversible and competitive inhibitors of MAO-B with Ki values of 0.014 and 0.0071, respectively. Moreover, T6 was less toxic to healthy fibroblast cells (L929) than T3. Molecular docking simulations with MAO binding sites returned higher docking scores for T6 and T3 with MAO-B than with MAO-A. These results suggest that T3 and T6 are selective, reversible, and competitive inhibitors of MAO-B and should be considered lead candidates for the treatment of neurodegenerative disorders like Alzheimer’s disease.
