Abstract We investigate the scale on which the correlation arises between the 843 MHz radio and the 60 μm far-infrared (FIR) emission from star forming regions in the Milky way. The correlation, which exists on the smallest scales investigated (down to ≈ 4 pc), becomes noticeably tight on fields of size 30′, corresponding to physical scales of ≈ 20–50 pc. The FIR to radio flux ratio on this scale is consi stent with the radio emission being dominated by thermal emission. We also investigate the location dependence of q mean , a parameter measuring the mean FIR to radio flux ratio, of a sample of star forming regions. We show that q mean displays a modest dependence on galactic latitude. If this is interpreted as a dependence on the intensity of star formation activity, the result is consistent with studies of the Large Magellanic Cloud (LMC) and other near by galaxies that show elevated values for q in regions of enhanced star formation.
No abstract is provided for this article.
There is an urgent need to develop more effective therapies for chronic obstructive pulmonary disease (COPD) that target the underlying inflammatory disease process. Current therapies with long-acting bronchodilators and inhaled corticosteroids fail to prevent either disease progression or mortality, as they do not suppress the underlying inflammation. With better understanding of the inflammatory and destructive process in the pathophysiology of COPD, several new therapeutic targets have been identified. Several mediator antagonists or inhibitors tested in COPD have so far been disappointing. Broad-spectrum anti-inflammatory drugs may be more effective, and include inhibitors of the proinflammatory enzymes phosphodiesterase-4, p38 mitogen-activated protein kinase, Janus-activated kinases, NF-κB kinase, and PI3kinase-γ and -δ, but side effects after oral administration are a major limitation; therefore, in future inhaled delivery may be necessary. A new promising approach is reversal of corticosteroid resistance through increasing histone deacetylase-2 activity. This might be achieved by existing treatments such as theophylline, nortriptyline, and macrolides, or more selectively by PI3kinase-δ inhibitors. Other treatments in development target oxidative stress, the failure to resolve inflammation, aberrant repair mechanisms, and accelerated lung aging.
No abstract is provided for this article.
Vasodilatory effects of nicorandil on major coronary arteries were investigated in 22 patients undergoing cardiac catheterization. Nicorandil, 20 mg, was administered sublingually to 11 consecutive patients and 40 mg to 11 others. Systemic blood pressure decreased significantly without affecting the heart rate. A total of 103 selected coronary artery segments, including 17 stenotic segments, were analyzed quantitatively using a computer-assisted coronary angiographic analysis system. After administration of 20 or 40 mg of nicorandil, a significant increase of the mean diameter was observed in the proximal (+9% and +7%), midportion (+10% and + 11%) and distal (+15% and +13%) parts of the left anterior descending coronary artery. Corresponding values for the proximal (+13% and +10%) and distal (+10% and +15%) segments of the circumflex artery were observed. An increase in the obstruction diameter was also observed in all but 3 of the analyzed stenotic segments. The results demonstrate that nicorandil, in the route and doses used, causes significant vasodilatation in the normal epicardial coronary segments as well as in most of the stenotic segments.
Axially compressed circular cylindrical shells with large diameter-to-thickness ratios are highly susceptible to local buckling, and their load-carrying capacities are known to be very sensitive to initial geometric imperfections. Hence, severe knock-down factors on their theoretical buckling loads are typically prescribed in design specifications, which greatly impair their structural efficiency. With the aim of enhancing load-bearing resistance and reducing sensitivity to imperfections, the shape optimisation and assessment of compressed free-form wavy cylindrical shells, the realisation of which is now viable through additive manufacturing, are the subject of the present study. The adopted optimisation framework employs the Particle Swarm Optimisation (PSO) algorithm, integrating computer-aided geometric design, nonlinear numerical simulations and imperfection sensitivity analyses. The structural performance of the optimised free-form wavy shells is analysed and compared to that of reference circular shells, as well as other types of non-circular shell profiles, including sinusoidally corrugated shells, Aster shells and stringer-stiffened shells. The optimised free-form wavy shell profiles are shown to exhibit increases in ultimate stress of up to 136% compared with the reference circular shell profiles; in general, greater benefits are achieved for more slender cross-sections. In future work, the proposed optimised shells will be manufactured in stainless steel by means of powder bed fusion (PBF), and their structural performance will be further verified through physical experiments.
