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Ein oligomeres Rückgrat aus Piperidinringen kann sowohl in Lösung als auch durch Festphasensynthese erhalten werden. Diese Oligomere nehmen gut definierte, stäbchenförmige Strukturen an, in denen alle Piperidinreste in Lösung (D2O, CD3OD) wie im festen Zustand eine Sesselkonformation haben (siehe Bild).

Nanoscience offers the promise of producing revolutionary advances in many areas of science and technology, ranging from electronics and computing to biology and medicine, yet the realization of this promise will depend critically on the rational development of unique nanoscale structures whose properties and/or function are controlled during materials synthesis. This review will illustrate these concepts using nanowires as a platform material. First, a brief historical perspective on emergence of nanowires as a central material will be presented. Second, the `chemical' synthesis, atomic-level structural characterization and properties of complex modulated nanowires will be discussed with an emphasis on structures with radial and axial dopant modulation, and novel but controlled structural modulations. The implementation of these functional nanowires as a platform for investigating fundamental properties and performance limits of nanoscale quantum electronic and photovoltaic devices at the single nanowire level will be described. Second, the development of active interfaces between nanowire nanoelectronic devices and biological systems will be discussed, including label-free electronic detection at the single molecule level and multiplexed recording from individual cells through complex biological tissue, such as the brain. In addition, the development of novel nanowire probes that exploit unique synthetic capabilities for the nanowire platform and move beyond capabilities of conventional electrophysiological techniques will be discussed. Last, a critical look at progress made and scientific challenges that remain to realize true technologies in the future will be reviewed.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic Filtration of Small Heterogeneous Catalyst Particles. Preparation of Ferrimagnetic Catalyst SupportsGeorge M. Whitesides, Craig L. Hill, and Jean-Claude BrunieCite this: Ind. Eng. Chem. Process Des. Dev. 1976, 15, 1, 226–227Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/i260057a040https://doi.org/10.1021/i260057a040research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

We briefly review tunneling spectroscopy studies of the new fullerene-based superconductors, K 3 C 60 and Rb 30 C 60 from our laboratory. At low temperature the reduced energy gap, 2∆/ k T c , has a value of 5.3 ± 0.2 and 5.2 ± 0.3 for K 3 C 60 and Rb 3 C 60 , respectively. The magnitude of the reduced gap for these materials is significantly larger than the value of 3.53 predicted by BCS theory. These results demonstrate that the energy gap scales with T c and show that the pair coupling interaction is strong in the M 3 C 60 superconductors, and thus they provide information essential to understanding superconductivity in the M 3 C 60 materials.

No abstract is provided for this article.

OBJECTIVE The fat mass and obesity-associated gene (FTO) variant has shown the strongest association with obesity. Recent studies suggest that dietary intake may modify the genetic effects of FTO. We tested the effect of FTO variant on long-term weight loss and change in body composition in a 2-year randomized intervention trial. RESEARCH DESIGN AND METHODS FTO SNP rs1558902 was genotyped in 742 overweight or obese adults who were randomly assigned to one of four diets differing in the percentages of energy derived from fat, protein and carbohydrate (20, 15, and 65%; 20, 25, and 55%; 40, 15, and 45%; and 40, 25, and 35%) in the Pounds Lost Trial for 2 years. Body composition and fat distribution were measured in 424 and 195 participants by Dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively. RESULTS We found significant modification effects for diet intervention varying in protein (low vs high), but not in fat, on 2-year changes in total fat, fat free mass (FFM), fat mass% (FM%), trunk fat%, total adipose tissue mass (TAT), visceral adipose tissue mass (VAT) and superficial adipose tissue mass (SAT) (P for interactions=0.045, 0.036, 0.033, 0.048, 0.001, 0.008 and 0.002, respectively). Carriers of the risk allele (A allele) had a greater loss of weight and regional fat in response to high protein diet, while an opposite genetic effect was observed on changes in TAT and SAT in response to low protein diet at 2 years. Significant gene by diet interventions (low vs high protein) were also observed at 6 months of intervention, when the maximum of weight-loss was achieved, for changes in FFM, TAT, VAT and SAT (P for interactions=0.007, 0.019, 0.036 and 0.041, respectively). Patterns of change in body composition and fat distribution by diet intervention were similar at 6 month and 2 year. CONCLUSIONS Our data suggest that a high-protein diet may be beneficial for weight loss in individuals with the risk allele of the FTO variant rs1558902.

The prevalence of severe obesity continues to surge despite a rapid increase in the use of weight loss surgery (WLS) ((1),(2)). The number of operations climbed 900% from 1998 to 2004 (ref. (3)), and another 11% between 2005 and 2006, growing from ∼180,000 (ref. (4)) to an estimated 200,000 (refs. (1),(4)). WLS generates substantial, sustainable weight loss and improvements in obesity-related comorbidities ((5),(6)). Mounting evidence also indicates significant survival advantages in WLS patients compared with their untreated peers ((7),(8),(9),(10),(11),(12)). Benefits notwithstanding, there are associated risks of surgery, including a nationwide mortality rate of ∼1% and a morbidity rate of 20% ((6)). This issue of Obesity addresses these risks with a series of evidence-based updates to best practice recommendations published in 2005 (ref. (13)). Findings in these reports are based on a comprehensive review of the most current literature on WLS. They directly link patient safety to methods for setting evidence-based guidelines developed from peer-reviewed scientific publications ((14)). This approach has been accepted as a reasonable and rational way to make decisions about the individual care of patients ((15)). We believe that it is a valid route to best practice recommendations, not only in the field of WLS, but in other areas of medicine as well ((14)). More than 100 specialists from across the state and across the many disciplines involved in WLS came together to develop these new standards. They assessed the quality, impact, and applicability of evidence from comprehensive literature review, and integrated extensive clinical expertise with the latest findings from systematic research ((13),(14),(15)). Their recommendations, vetted through informed discussion, are peer-reviewed and consensus-based ((16)). Guidelines developed in this way provide an unbiased summary of the latest science. They advance patient safety in a field that is subject to rapid technological and demographic change. Risks and opportunities in such environments create an imperative for a systematic approach to the evaluation of new surgical approaches, the accreditation process for training ((16)), and procedures for delivering comprehensive, long-term multidisciplinary care. In this supplement, a total of 11 separate task groups present these and other issues in a series of evidence-based reports. The Surgical Care task group ((17)) covers the safety and efficacy of WLS options, including those on the leading edge of care. It also delves into pertinent issues in patient selection and credentialing standards. The Multidisciplinary Evaluation and Treatment group ((18)) focuses on the expanding scope of expertise required to optimize short- and long-term outcomes, including exercise physiology and body contouring surgery. Other task groups summarize new and compelling science in perioperative nursing ((19)), behavioral and psychological care ((20)), pediatric/adolescent WLS ((21)), and anesthetic perioperative care and pain management ((22)). This supplement includes articles on every facet of WLS related to patient safety, from informed consent ((23)) and data collection ((24)) to detailed specifications on the equipment and facilities required to meet the needs of extremely obese patients ((25)). The Policy and Access group ((26)) speaks to healthcare disparities in WLS and issues surrounding stigma, childhood obesity, third party coverage, and the management of innovation. The Endoscopic Interventions group ((27)) reports on an emerging field at the frontier of minimally invasive WLS. With up to 1 in 10 US adults a potential candidate for WLS ((28)), these findings are of particular relevance. The reach of this Lehman Center report, like that of its predecessor ((13)), will extend beyond the covers of this journal. It will be submitted to the Agency for Healthcare Research and Quality (AHRQ) ((29)) for abstracting. It will form the basis for the second International Patient Safety in Weight Loss Surgery, a Harvard Medical School CME program for surgeons, anesthesiologists, internists, and other healthcare professionals. It will be presented to the Public Health Council, the Massachusetts Department of Public Health's regulatory body ((30)). The first Lehman Center report set the standard of care for WLS in Massachusetts and beyond, but much has changed since its development in 2004. The body of knowledge contained in the literature has increased substantially in size and quality. The growing need for effective treatment has prompted new or revised WLS procedures (e.g., biliopancreatic diversion and sleeve gastrectomy). And numerous efforts are underway to advance investigational approaches, such as interventional endoscopy ((27)) and implantable gastric stimulation ((31)). Other changes have been brought about by the actions of professional societies and credentialing bodies. Since 2004, accreditation programs have been launched by the American Society for Metabolic and Bariatric Surgery/Surgical Review Corporation (ASMBS/SRC) ((32)) and the American College of Surgeons (ACS) ((33)). These efforts are sanctioned by the Centers for Medicare and Medicaid Services ((34)), which will only cover WLS carried out in facilities that meet standards of excellence established by these organizations. Such advances notwithstanding, the field of WLS is maturing in fits and starts. As the US population becomes older, and increasingly obese ((1)), the government is stepping up efforts to standardize data collection and track short- and long-term WLS outcomes ((35)). At the same time, some health insurance companies have moved to restrict or deny coverage based on incomplete, inaccurate, or biased information ((36)). We expect these updated recommendations to counter such measures and advance efforts to deliver safe and equitable best practice care. This report from the Expert Panel on WLS has been requested and funded by the Betsy Lehman Center for Patient Safety and Medical Error Reduction (Lehman Center). Its purpose is to improve the safety and well-being of patients who undergo WLS in the Commonwealth of Massachusetts. Since the publication of the original Lehman Center guidelines ((13)) in 2005, certain hospitals in the state have discontinued their WLS programs, while new ones, accredited by the ASMBS/SRC or the ACS, have entered the field. Since 2005, the mortality rate for WLS in the state of Massachusetts has been 0.25%, far below the national average. The earlier version of this document achieved its objectives. It was also instrumental in shaping policy and setting best practice standards on a national and international scale ((37),(38),(39),(40)). We expect nothing less from this update. To review task group appendices, go to www.mass.govdph and search “Weight Loss Surgery.” We thank Rita Buckley for editorial services provided in the development of this manuscript.