6,332 publications from this institution
Obesity affects the majority of women with polycystic ovary syndrome (PCOS), but previous studies are inconsistent about the prevalence of obesity and the importance of weight gain in the development of the syndrome. Our objective was to explore the association between weight, weight gain, hyperandrogenism, and PCOS from adolescence to late adulthood. The study includes a prospective Northern Finland Birth Cohort 1966 study including 5889 females born in 1966 and followed at the ages of 14, 31, and 46 years. The setting was the general community. Women presenting both oligo/amenorrhea (OA) and hirsutism (H) at age 31 (N = 125) or with formally diagnosed PCOS by age 46 (N = 181) were compared with women without PCOS symptoms or diagnosis (n = 1577). None. Body mass index (BMI), weight change through life, waist circumference, Free Androgen Index, lipids, glucose, insulin, high-sensitivity C-reactive protein, homeostatic model assessment for insulin resistance, and PCOS. Women with OA+H at age 31 or diagnosis of PCOS by age 46 had the highest BMI at all ages compared with the controls. Increase of BMI between ages 14 and 31, but not between 31 and 46, was greater in women with isolated OA (P = .006), OA+H (P = .001), and diagnosis of PCOS (P = .001) compared with controls. In the multivariate analysis, PCOS was significantly associated with BMI at all ages (BMI at age 31: odds ratio [OR] = 1.05 [95% confidence interval (CI), 1.00–1.10], Free Androgen Index (OR = 1.08 [95% CI, 1.03–1.14]), serum levels of insulin (OR = 1.05 [95% CI, 1.00–1.09]), and triglycerides (OR = 1.48 [95% CI, 1.08–2.03]). Symptoms or diagnosis of PCOS are associated with dyslipidemia, hyperandrogenemia, and significantly increased weight gain, especially in early adulthood. This observation is important because it may identify a sensitive time period when weight gain plays a crucial role in the emergence of PCOS and when preventive actions against metabolic and cardiovascular diseases should be implemented.
No abstract is provided for this article.
Background: fuelled by rapid urbanization and changes in dietary and lifestyle choices, cardiovascular disease (CVD) has emerged as the leading cause of death in China. Purposes: to estimate the CVD events that potentially contributed to 9 modifiable dietary, lifestyle, and metabolic risk factors in China. Methods: We used data on risk factor exposures in the Chinese population from nationally representative health surveys and CVD morbidity and mortality statistics from the China Health Statistical Yearbook and the National Population Census. We obtained the etiological effects of risk factors on CVD risk, by age, from systematic reviews and meta-analyses of epidemiological studies. We estimated the number of CVD events attributable to all non-optimal levels of each risk factor exposure, by urban/rural, age and sex. Results: Based on the exposure distribution estimated by 2009 China Health Nutrition Survey, the population attributable risk (PAR) on CVD events was 47.3% for high blood pressure, 23.2%, for physical inactivity, 18.5% for smoking, 13.5 for high BMI, 13.0% for high LDL cholesterol, 11.8% for high blood glucose, 11.1% for low dietary intakes of fruit and vegetable, 7.1% for high sodium intake and 3.5% for low PUFA intake, which was 78.0%, 18.8%, 20.9%, 21.9%, 8.2%, 16.1%, 12.0%, 20.3% and 2.0%, respectively, based on exposure distribution of 2002 China National Nutrition and Health Survey. In 2009, high blood pressure was responsible for 3.9 million CVD events, including 1.4 million CHD, 1.5 million ischemic strokes and 1 million hemorrhagic strokes. Large gender difference was found for PAR% of smoking (male 27.8%/female 6.5%). Conclusions: High blood pressure, smoking and physical inactivity, which all have effective interventions, are responsible for the largest number of CVD events in China. Other dietary, lifestyle, and metabolic risk factors for chronic diseases also cause a substantial number of CVD morbidity and mortality in China.
OBJECTIVE: An association between the type 4 dopamine receptor (DRD4) gene and the behavioral trait of novelty seeking has been reported, but several studies have failed to replicate this finding. In the present study, the authors tested for this association in a representative sample from the Finnish population. METHOD: The authors administered the Temperament and Character Inventory to 4,773 individuals from the 1966 birth cohort of northern Finland. They then genotyped 190 subjects with extreme scores for a 48 base-pair repeat polymorphism in the DRD4 gene. RESULTS: There was a significant difference in allele frequencies between the two groups. The 2- and 5-repeat alleles were significantly more common in the group of high scorers than in the group of low scorers. CONCLUSIONS: These results confirm the original findings of an association between the DRD4 gene and novelty seeking, while showing that novelty seeking is probably not influenced by the polymorphism itself but, rather, a different DNA variant in the DRD4 gene or another gene in linkage disequilibrium with it.
Constitutive relations for fault slip are described and adopted as a basis for analyzing slip motion and its instability in the form of earthquakes on crustal faults. The constitutive relations discussed include simple rate-independent slip-weakening models, in which shear strength degrades with ongoing slip to a residual frictional strength, and also more realistic but as yet less extensively applied slip-rate and surface-state-dependent relations. For the latter the state of the surface is characterized by one or more variables that evolve with ongoing slip, seeking values consistent with the current slip rate. Models of crustal faults range from simple, single-degree-of-freedom spring-slider systems to more complex continuous systems that incorporate nonuniform slip and locked patches on faults of depth-dependent constitutive properties within elastic lithospheric plates that may be coupled to a viscoelastic asthenosphere. Most progress for the rate and state-dependent constitutive relations is at present limited to single-degree-of-freedom systems. Results for stable and unstable slip with the various constitutive models are summarized. Instability conditions are compared for spatially uniform versus nonuniform slip, including the elastic—brittle crack limit of the nonuniform mode. Inferences of constitutive and fracture parameters are discussed, based on earthquake data for large ruptures that begin with slip at depth, concentrating stress on locked regions within a brittle upper crust. Results of nonlinear stability theory, including regimes of complex sustained stress and slip rate oscillations, are outlined for rate and state-dependent constitutive relations, and the manner in which these allow phenomena like time-dependent failure, restrengthening in nearly stationary contact, and weakening in rapidly accelerated slip, is discussed.
No abstract is provided for this article.
The biomimetic self-assembly of an operating electrical circuit is described. The circuit, self-assembled via the hydrophobic effect from two different, but shape-complementary, non-functional subunits, contains a light-emitting diode (LED), a gold cathode, and a magnesium anode. It is shown that the system, when immersed in a suitable electrolyte (potassium ferricyanide), constitutes an electrochemical cell—the LED is powered through a reaction involving the dissolution of magnesium(0) at the anode and the reduction of ferricyanide to ferrocyanide at the cathode.
