Publications

The area under the plasma drug concentration-time curve (AUC), representing the total drug exposure over time, is a common pharmacokinetic (PK) surrogate to inform the issue of therapy. Reliability of its estimation highly depends on the frequency of blood sampling. To reduce the cost and inconvenience of blood withdrawal, limited sampling strategies (LSS) have been proposed, with two main approaches for their development and implementation, whether the multiple linear regression-based LSS (R-LSS) or the Bayesian-based LSS (B-LSS). Regardless of the method used, evaluation of the predictive capacity of LSS is critical. Transferring an LSS between different clinical settings is an overlooked aspect, threatening thus the extension of its informed use. In the current paper, we study the reliability of a chosen LSS by proposing a hybrid approach that takes advantage of both R-LSS and B-LSS to analyze its robustness and success rate. The impact of variability on the LSS reliability is also investigated. As a result, we were able to show that our method enhances the selection of the best LSS and informs the associated risk to their transferability. This simulation-based methodology should be added to routine procedures of LSS development to complement traditional validations.

As a new functional material,foam aluminum is of characteristics of sound absorption and vibration attenuation.A type of composite structure consisting of a foam aluminum layer and base plates is put forward.The sound insulation performance is investigated.The method for computation of sound transmission loss for normal wave incidence is developed.The influences of different thickness of the foam aluminum layer on the transmission loss of the structure are analyzed by numerical method.The results are in good agreement with those of experimental testing.It is found that the thickness of foam aluminum has a great impact on the sound transmission loss of the composite structure.

To solve the bonding question of fiber with the column structure, the bonded fiber Bragg grating strain sensor was introduced.The sensor was mounted on the surface of cantilever girder, where the strain was derived from the loading, and these reflected spectra of grating followed by the variation of strain were obtained by optical analyzer. The experiment denotes that the response of wavelength shift of the grating to the loading is 0.901 nm/μm and -0.902 nm/μm. The computation shows that the maximum standard error was 0.003 nm.The result indicates that the sensor can be satisfied with the precision demand of structural measurement in architecture engineering.

In this paper, we propose a speckle suppression method for SAR image based on dual-tree complex wavelet. Non-Gaussian bivariate distribution model is proposed by considering the correlation of the real and imaginary parts of complex wavelet coefficients. Based on this model, the shrinkage function of real and imaginary parts of complex coefficients is obtained with the help of maximum a posteriori estimate. Compared with the state-of-the-art techniques through the visual effect and the equivalent number of looks (ENL), experimental results demonstrate that the proposed algorithm obtains good performance in smoothing speckles of homogeneous regions and preserving edges and details effectively.

Engineering design must take care of local peaks within stress field, in order to provide relevant forecast of material behavior. Within pipeline girth welds, pipe misalignment is an ordinary cause of significant stress concentrations. The matching of pipe ends depends of the quality of alignment procedure but it is also much influenced by pipe fabrication tolerances. In general, misalignment is estimated considering the maximal and minimal values of each pipe size according to pipe fabrication tolerances. But, in practice, the probability to get a such case is very low. This paper describes how to improve the calculation of stress concentration factor (SCF) through a statistical analysis of pipe dimensions. The use of actual pipe measurements is not necessary even if it provides better SCF estimation. Indeed the distribution of pipe size can be estimated through the fabrication tolerances which require acceptable capacities of the manufacturing system.

The dynamic visualization system for risk characterization and accident evolution of molten metal operation takes steel smelting and electrolytic aluminum as scenes, taking the four typical accidents of explosion, spitting, tilting and leakage as the objects, 3Dmax+Substance Painter2 are used for modeling and mapping, and Unity3d+C# are used for development. The system consists of steel smelting and electrolytic aluminum subsystems, including the functional modules such as hazard & risk characterization, accident rehearsal, accident reconstruction, safety cognition, etc. It is expected to provide operators, managers and other relevant personnel with effective tools for accident evolution analysis, accident deduction analysis, and safety cognition, to reduce accidents.