Background and Objectives: Asymptomatic bacteriuria (ASB) is prevalent in kidney transplant recipients (KTRs) and is hypothesized to heighten the risk of subsequent urinary tract infections (UTIs). Whether antibiotic treatment of ASB in KTRs is beneficial has not been elucidated. Materials and Methods: We carried out a systematic review and meta-analysis of all randomized controlled trials (RCTs) and quasi-RCTs that examined the merits of managing asymptomatic bacteriuria in KTRs. The primary outcomes were rates of symptomatic urinary tract infections (UTIs) and antimicrobial resistance. Results: Five studies encompassing 566 patients were included. No significant difference in symptomatic UTI rates was found between antibiotics and no treatment groups (relative risk (RR) 1.05, 95% confidence interval (CI) = 0.78–1.41), with moderate heterogeneity (I2 = 36%). Antibiotic treatment was found to present an uncertain risk for the development of drug-resistant strains (RR = 1.51, 95% CI = 0.95–2.40, I2 = 0%). In all trials, no significant difference between study arms was demonstrated regarding patient and graft outcomes, such as graft function, graft loss, hospitalization due to UTI, all-cause mortality, or acute rejection. Conclusions: The practice of screening and treating kidney transplant patients for asymptomatic bacteriuria does not curtail the incidence of future symptomatic UTIs, increase antimicrobial resistance, or affect graft outcomes. Whether early treatment of ASB after kidney transplantation (<2 months) is beneficial requires more RCTs.
In this investigation, it is showed for the first time that a piezoelectric poly‐( l ‐lactic acid) (PLLA) unimorph based cantilever device is utilized in energy harvesting applications. The cantilever device comprises of double layer of PLLA and a thick layer of polyethylene terephthalate substrate as a passive layer. Under the optimized conditions, the output power of the PLLA cantilever devices can reach a maximum value of 14.17 µW, and an open circuit voltage of 9.05 V. The generated signal can be rectified through a full‐bridge circuit and used to charge a lithium‐ion battery to 3.2 V within 7.5 h. The charged battery can successfully light up 30 light‐emitting diodes for two minutes. Furthermore, after the PLLA film was thermally treated at 140 °C for 24 h, the material still shows a shear mode piezoelectric coefficient d 14 of 9.57 pC N −1 . The cantilever device fabricated from a double layer of thermally treated PLLA film can still generate an output voltage of 9.4 V and a slightly higher power output of 14.45 µW. This observation indicates that the PLLA material can be used to replace piezoelectric polymers with a lower Curie temperature in self‐powered devices under high temperature conditions.
The development of active and inexpensive electrocatalysts for the oxygen evolution reaction (OER) to promote water splitting has always been a major challenge. Cobalt-based oxides and sulfides have been actively investigated due to their low cost and high activity. However, the lower intrinsic conductivity of cobalt oxide and the inferior stability of cobalt sulfides still limit their practical application. Herein, CoO was chosen for a proof-of-concept study in which the anion-doping strategy was used to obtain an excellent catalyst. Sulfur incorporation optimizes the charge-transfer properties and active sites of sulfur-doped CoO (S-CoO) and thus gives rise to improved catalytic activity. Besides sulfur doping, the stable framework of the cobalt oxide was well maintained, and thus high stability of S-CoO throughout the reaction process was ensured.