Abstract Widely distributed across the environment, irregular micro‐nano mechanical high entropy energy (HEE) is a new promising recoverable energy, in which the development of matched harvesting technology is imperative to fit in with the requirements of booming sustainable energy in the new era. The triboelectric nanogenerator (TENG) is a very efficient technology for harvesting micro‐nano HEE, especially when converting irregular, low‐frequency, weak mechanical energy into electricity. Here, the latest advancements are comprehensively reviewed in using TENGs for sustainable energy, sensing, and other applications. The fundamental theory and overwhelming superiority of TENG is systematically analyzed as a sustainable energy with four representative domains: micro‐nano distributed power sources, self‐powered sensing systems, direct high‐voltage power sources, and large‐scale blue energy. The review is concluded with a discussion of the challenges of leveraging TENGs for sustainable energy engineering. The striving directions of TENG technologies are proposed with a concentration on basic research and commercialization for the new ear of 5G and Internet of Things.
Experimentally, females show an improved ability to recover from ischemia-reperfusion injury (IRI) compared with males; however, this sex-dependent response is less established in humans. Here, we developed a series of murine renal ischemia and transplant models to investigate sex-specific effects on recovery after IRI. We found that IRI tolerance is profoundly increased in female mice compared with that observed in male mice and discovered an intermediate phenotype after neutering of either sex. Transplantation of adult kidneys from either sex into a recipient of the opposite sex followed by ischemia at a remote time resulted in ischemia recovery that reflected the sex of the recipient, not the donor, revealing that the host sex determines recovery. Likewise, renal IRI was exacerbated in female estrogen receptor α–KO mice, while female mice receiving supplemental estrogen before ischemia were protected. We examined data from the United Network for Organ Sharing (UNOS) to determine whether there is an association between sex and delayed graft function (DGF) in patients who received deceased donor renal transplants. A multivariable logistic regression analysis determined that there was a greater association with DGF in male recipients than in female recipients. Together, our results demonstrate that sex affects renal IRI tolerance in mice and humans and indicate that estrogen administration has potential as a therapeutic intervention to clinically improve ischemia tolerance.